{"id":710,"date":"2022-03-10T15:25:25","date_gmt":"2022-03-10T07:25:25","guid":{"rendered":"http:\/\/www.tarzan-tech.com\/?p=710"},"modified":"2022-08-27T18:07:24","modified_gmt":"2022-08-27T10:07:24","slug":"adient-is-a-global-leader-in-automotive-seating","status":"publish","type":"post","link":"http:\/\/www.tarzan-tech.com\/en\/adient-is-a-global-leader-in-automotive-seating\/","title":{"rendered":"\u7f3a\u6c27\u80be\u810f\u635f\u4f24\u7814\u7a76"},"content":{"rendered":"

\"\u7f3a\u6c27\u80be\u810f\u635f\u4f24\u7814\u7a76\u63d2\u56fe\"<\/p>\n

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\u7f3a\u6c27\u80be\u810f\u635f\u4f24\u7814\u7a76<\/strong><\/span><\/section>\n<\/section>\n
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\u6162\u6027\u7f3a\u6c27\u53ef\u89e6\u53d1\u80be\u810f\u635f\u4f24\u53cd\u5e94\uff0c\u5e76\u53ef\u80fd\u523a\u6fc0\u80be\u5c0f\u7ba1\u8fd1\u7aef\u7ec6\u80de\u7684\u708e\u75c7\uff0c\u4ece\u800c\u5bfc\u81f4\u4e0d\u53ef\u9006\u7684\u75c5\u7406\u6539\u53d8\u3002\u00a0<\/p>\n
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\u4ec0\u4e48\u662f\u7f3a\u6c27\u80be\u810f\u635f\u4f24\uff1f<\/strong><\/span>\"\u7f3a\u6c27\u80be\u810f\u635f\u4f24\u7814\u7a76\u63d2\u56fe1\"<\/p>\n
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\u00a0 \u00a0 \u00a0 \u00a0\u6c27\u7a33\u6001\u662f\u7ef4\u6301\u6b63\u5e38\u80fd\u91cf\u4ea7\u751f\u7684\u4e00\u4e2a\u91cd\u8981\u56e0\u7d20\u3002\u80be\u810f\u662f\u7f3a\u6c27\u65f6\u6700\u5bb9\u6613\u53d7\u635f\u7684\u5668\u5b98\u4e4b\u4e00\u3002\u7814\u7a76\u8868\u660e\uff0c\u6162\u6027\u7f3a\u6c27\u53ef\u89e6\u53d1\u80be\u810f\u635f\u4f24\u53cd\u5e94\uff0c\u5e76\u53ef\u80fd\u523a\u6fc0\u80be\u5c0f\u7ba1\u8fd1\u7aef\u7ec6\u80de\u7684\u708e\u75c7\uff0c\u4ece\u800c\u5bfc\u81f4\u4e0d\u53ef\u9006\u7684\u75c5\u7406\u6539\u53d8\u3002<\/strong>\u5728\u4e00\u5b9a\u7a0b\u5ea6\u7684\u7f3a\u6c27\u6761\u4ef6\u4e0b\uff0c\u80be\u810f\u5177\u6709\u81ea\u6211\u4fdd\u62a4\u673a\u5236\u53ca\u5176\u5bf9\u7f3a\u6c27\u7684\u9002\u5e94\u673a\u5236\u3002\u7814\u7a76\u8868\u660e\uff0c\u7f3a\u6c27\u8bf1\u5bfc\u56e0\u5b501\u03b1(HIF-1\u03b1)\u5728\u7f3a\u6c27\u635f\u4f24\u540e\u8868\u8fbe\u9010\u6e10\u589e\u52a0\uff0cHIF-1\u03b1\u53ef\u8c03\u8282\u4e0b\u6e38\u57fa\u56e0\u7684\u8868\u8fbe\uff0c\u589e\u52a0\u5bf9\u635f\u4f24\u7ec4\u7ec7\u7684\u6c27\u4f20\u9012<\/strong>\u3002\u8fd9\u4e9b\u53d1\u73b0\u63d0\u793a\uff0c\u5728\u6162\u6027\u7f3a\u6c27\u6761\u4ef6\u4e0b\uff0c\u53ef\u80fd\u5b58\u5728\u4e00\u79cd\u6297\u80be\u810f\u635f\u4f24\u7684\u81ea\u6211\u4fdd\u62a4\u673a\u5236\u3002\u7814\u7a76\u8868\u660e\uff0cHIF-1\u03b1\u53c2\u4e0e\u4e86\u5bf9\u80be\u810f\u7f3a\u6c27\u7684\u9002\u5e94\u673a\u5236\u3002\u5728\u5e38\u6c27\u6761\u4ef6\u4e0b\uff0cHIF\u88ab\u6cdb\u7d20\u4f9d\u8d56\u7684\u86cb\u767d\u9176\u4f53\u964d\u89e3\uff1b\u7136\u800c\uff0c\u7f3a\u6c27\u5374\u7a33\u5b9a\u4e86HIF\u7684\u8868\u8fbe\uff0c\u4ece\u800c\u4e0a\u8c03\u4e86\u53c2\u4e0e\u7f3a\u6c27\u9002\u5e94\u7684\u9776\u57fa\u56e0\u7684\u8868\u8fbe\u3002\u4e3a\u4e86\u54cd\u5e94HIF-1\u03b1\u7684\u6fc0\u6d3b\uff0c\u591a\u4e2a\u57fa\u56e0\u4ea7\u7269\u88ab\u8868\u8fbe[\u5305\u62ec\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50(VEGF)]\uff0c\u901a\u8fc7\u4fc3\u8fdb\u8840\u7ba1\u751f\u6210\u6765\u62b5\u6d88\u7f3a\u6c27\u3002VEGF\u8868\u8fbe\u4e0b\u8c03\u548c\u6297\u8840\u7ba1\u751f\u6210\u56e0\u5b50\u8868\u8fbe\u4e0a\u8c03\u53ef\u5bfc\u81f4\u8840\u7ba1\u751f\u6210\u5931\u8c03\u7684\u53d1\u751f\uff0c\u6700\u7ec8\u5bfc\u81f4\u8fdb\u884c\u6027\u80be\u8870\u7aed\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u7f3a\u6c27\u6fc0\u6d3b\u4e86HIF\u901a\u8def\uff1b\u7136\u800c\uff0c\u5728\u4e25\u91cd\u7684\u7f3a\u6c27\u6761\u4ef6\u4e0b\uff0cHIF\u901a\u8def\u7684\u8868\u8fbe\u88ab\u4e0b\u8c03\u3002\u4e3a\u6b64\uff0c\u4e0a\u6d77\u4ea4\u901a\u5927\u5b66\u9644\u5c5e\u65b0\u534e\u533b\u9662\u7814\u7a76\u56e2\u961f\u5bf9\u6b64\u8fdb\u884c\u4e86\u76f8\u5173\u7814\u7a76\uff0c\u5b9e\u9a8c\u6210\u679c\u53d1\u8868\u57282021\u5e74\u7684\u3010Frontiers in Physiology\u3011\u671f\u520a\u4e0a\u3002<\/span><\/p>\n

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\u5b9e\u9a8c\u7814\u7a76<\/strong><\/span><\/p>\n

\u7814\u7a76\u91c7\u752830\u53ea5\u5468\u9f84SD\u5927\u9f20\uff0c\u8fdb\u884c\u4e0d\u540c\u6761\u4ef6\u7684\u7f3a\u6c27\u9020\u6a21\u3002<\/p>\n

\u4f20\u7edf\u4e0a\uff0c\u5bf9\u4e8e\u6162\u6027\u7f3a\u6c27\u6a21\u578b\uff0c\u5927\u9f20\u63a5\u53d72\u5468\u7f3a\u6c27(10% O2)\u3002\u6c27\u5408\u76ee\u6807(Pa O2 90-60mmHg)\u662f\u901a\u8fc7\u8c03\u6574\u5438\u6c14\u6c27\u6c14\u7684\u5206\u6570(Fi O2)\u6765\u5b9e\u73b0\u7684\uff0c\u5bf9\u4e8e\u9ad8\u751f\u5b58\u7387\u548c\u4f4ePaO2\u6c34\u5e73\uff0c\u7814\u7a76\u4eba\u5458\u5728\u7814\u7a76\u4e2d\u6d4b\u91cf\u7684\u6700\u5c0fO2\u6d53\u5ea6\u4e3a7% O2\u3002\u8001\u9f20\u968f\u673a\u5206\u5e03\u6210\u4e09\u7ec4\u6839\u636e\u5438\u5165\u4e0d\u540c\u6d53\u5ea6\u7684\u6c27\u6c14\uff08\u6bcf\u7ec4\u5305\u62ec10\u53ea\u52a8\u7269\uff09\uff1a21% O2\u5728B\u7ec4\uff0c10% O2\u548c7% O2\u7ec4\u6bcf\u7ec4\u8fdb\u4e00\u6b65\u5206\u4e3a\u4e24\u4e2a\u5b50\u7ec4\u6839\u636e\u7f3a\u6c27\u65f6\u95f4\uff081\u62162\u5468\uff09\uff08\u56fe1\uff09<\/p>\n

\"\u7f3a\u6c27\u80be\u810f\u635f\u4f24\u7814\u7a76\u63d2\u56fe2\"<\/p>\n

\u6162\u6027\u5e38\u538b\u7f3a\u6c27\u66b4\u9732\uff08Chronic Hypoxia Exposure<\/strong>\uff09<\/section>\n
\u00a0 \u00a0 \u00a0 \u00a0\u5bf9\u7167\u7ec4\u5927\u9f20\u66b4\u9732\u4e8e21%\u7684O2\uff0c\u800c\u5b9e\u9a8c\u7ec4\u5927\u9f20\u66b4\u9732\u4e8e\u4e0d\u540c\u7a0b\u5ea6\u7684\u7f3a\u6c27\u81f3\u5c111\u5468\u3002\u7f3a\u6c27\u7ec4\u5927\u9f20\u7f6e\u4e8e\u5e38\u538b\u4f4e\u6c27\u8231(ProOx-100\uff0c\u4e0a\u6d77\u5854\u671b\u79d1\u6280\uff0c\u4e2d\u56fd)\u3002\u5bf9\u7167\u5e38\u6c27\u7ec4\u66b4\u9732\u5728\u5ba4\u5185\u7a7a\u6c14\u4e2d\uff0c\u7f3a\u6c27\u7ec4\u88ab\u653e\u7f6e\u5728\u7f3a\u6c27\u5ba4(\u6bcf\u7b3cn=5)\u3002\u6c27\u6d53\u5ea6\u8303\u56f4\u548c\u51c6\u786e\u6027\u5206\u522b\u4e3a0-25%\u548c0.1%\u3002\"\u7f3a\u6c27\u80be\u810f\u635f\u4f24\u7814\u7a76\u63d2\u56fe3\"<\/p>\n

*\u5982\u4e0a\u56fe\uff0c\u5854\u671b\u79d1\u6280\u53ef\u63d0\u4f9b<\/p>\n

\u00a0 \u00a0 \u00a0 \u00a0\u4f4e\u6c27\u7ed3\u675f\uff0c\u5927\u9f20\u6ce8\u5c04\u9ebb\u9189\u3002\u9ebb\u9189\u540e\uff0c\u5c06\u5927\u9f20\u4ef0\u5367\u4f4d\uff0c\u56fa\u5b9a\u5728\u624b\u672f\u53f0\u4e0a\u3002\u91c7\u7528\u8179\u4fa7\u4e2d\u7ebf\u5207\u53e3\u9694\u79bb\u8179\u4e3b\u52a8\u8109\uff0c\u5c06\u805a\u4e59\u70ef\u5bfc\u7ba1\u63d2\u5165\u8179\u4e3b\u52a8\u8109\uff0c\u5e76\u8fde\u63a5\u538b\u529b\u4f20\u611f\u5668\u8fdb\u884c\u6570\u636e\u91c7\u96c6\u8840\u538b\u6d4b\u91cf\u7cfb\u7edf\u3002\u901a\u8fc7\u8179\u4e3b\u52a8\u8109\u6d4b\u91cf\u8840\u538b\uff0c\u5e76\u91c7\u8840\u8fdb\u884c\u68c0\u6d4b\u3002<\/p>\n

\"\u7f3a\u6c27\u80be\u810f\u635f\u4f24\u7814\u7a76\u63d2\u56fe4\" \"\u7f3a\u6c27\u80be\u810f\u635f\u4f24\u7814\u7a76\u63d2\u56fe5\"<\/p>\n<\/section>\n

*\u5982\u4e0a\u56fe\uff0c\u5854\u671b\u79d1\u6280\u53ef\u63d0\u4f9b<\/p>\n

\u00a0 \u00a0 \u00a0 \u00a0\u7136\u540e\u5bf9\u8fd9\u4e9b\u5927\u9f20\u8fdb\u884c\u653e\u8840\u5b89\u4e50\u6b7b\u3002\u5207\u9664\u53cc\u80be\u8fdb\u884c\u5206\u6790\u3002\u5176\u4e2d\u4e00\u4e2a\u6807\u672c\u88ab\u95ea\u5b58\u51b7\u51bb\uff0c\u7acb\u5373\u4fdd\u5b58\u5728\u6db2\u6c2e\u5bb9\u5668\u4e2d\u8fdb\u884c\u514d\u75ab\u5370\u8ff9\u5206\u6790\uff0c\u800c\u53e6\u4e00\u4e2a\u6837\u54c1\u57284%\u591a\u805a\u7532\u919b\u6eb6\u6db2\u4e2d\u6d78\u6ce1\u8fdb\u884c\u7ea4\u7ef4\u56fa\u5b9a\uff0c\u7136\u540e\u8fdb\u884c\u67d3\u8272\u548c\u514d\u75ab\u7ec4\u5316\u68c0\u67e5\u3002\u5728\u5c3c\u5eb7EclipseE600\u663e\u5fae\u955c\u4e0b\u89c2\u5bdf\u7ec4\u7ec7\u5207\u7247\uff0c\u5e76\u4f7f\u7528\u5c3c\u5eb7DS-Ri1\u6570\u7801\u76f8\u673a\u62cd\u6444\u4e0d\u91cd\u53e0\u7684\u56fe\u50cf\u3002<\/p>\n

 <\/p>\n

\u90e8\u5206\u7ed3\u679c\u5982\u4e0b\uff1a<\/strong><\/p>\n

\"\u7f3a\u6c27\u80be\u810f\u635f\u4f24\u7814\u7a76\u63d2\u56fe6\"<\/p>\n

FIGURE 3 | The growth of rats and the weight of rat kidneys. (A) The mean body weight of the rats was determined on a daily basis for 14 consecutive days (10 rats were included in the analysis for the fifirst 7 days, and 5 rats were included for the remaining 7 days). (B) The renal hypertrophy index of rats on D7 (n = 5) and D14 (n = 5). (C) The mean left kidney weight of the rats was determined on D7 (n = 5) and D14 (n = 5). (D) The mean left kidney weight of the rats was measured on D7 (n = 5) and D14 (n = 5).<\/p>\n

\"\u7f3a\u6c27\u80be\u810f\u635f\u4f24\u7814\u7a76\u63d2\u56fe7\"<\/p>\n

FIGURE 4 | General features and morphological traits in renal tissues obtained from animals subjected to normoxic and hypoxic conditions. (A) Gross view of a kidney. (B) A histological section of kidney tissue. The histological examination was performed at 20 \u00d7 magnifification (scale bar = 100 \u00b5m).<\/p>\n

(C) Periodic acid-Schiff staining (40 \u00d7 magnifification, scale bar = 50 \u00b5m).<\/p>\n

(D) Masson\u2019s trichrome staining (40\u00d7 magnifification, scale bar = 50 \u00b5m).<\/p>\n

\"\u7f3a\u6c27\u80be\u810f\u635f\u4f24\u7814\u7a76\u63d2\u56fe8\" \"\u7f3a\u6c27\u80be\u810f\u635f\u4f24\u7814\u7a76\u63d2\u56fe9\" \"\u7f3a\u6c27\u80be\u810f\u635f\u4f24\u7814\u7a76\u63d2\u56fe10\"<\/p>\n<\/section>\n

FIGURE 7 | Double immunoflfluorescence labeling of CD31 (red) and \u03b1-SMA (green) in rat kidneys; nuclei are stained with DAPI (blue). (A) Mature blood vessel<\/p>\n

density of rats in the 21% O2 group. (B) Mature blood vessel density of rats in the 10% O2 group. (C) Mature blood vessel density of rats in the 7% O2 group.<\/p>\n

Original magnifification: \u00d7400<\/p>\n

 <\/p>\n<\/section>\n

\n<\/section>\n<\/section>\n<\/section>\n
\u53c2\u8003\u6587\u732e\uff1a<\/strong><\/section>\n
Yaya Xu, Xiangmei Kong, Jiru Li, Tiantian Cui, Yifan Wei, Jiayue Xu, Yueniu Zhu and Xiaodong Zhu*, Mild Hypoxia Enhances the Expression of HIF and VEGF and Triggers the Response to Injury in Rat Kidneys ,Frontiers in Physiology ,June 2021 | Volume 12 | Article 690496<\/section>\n<\/section>\n<\/section>\n<\/section>","protected":false},"excerpt":{"rendered":"

\u6162\u6027\u7f3a\u6c27\u53ef\u89e6\u53d1\u80be\u810f\u635f\u4f24\u53cd\u5e94\uff0c\u5e76\u53ef\u80fd\u523a\u6fc0\u80be\u5c0f\u7ba1\u8fd1\u7aef\u7ec6\u80de\u7684\u708e\u75c7\uff0c\u4ece\u800c\u5bfc\u81f4\u4e0d\u53ef\u9006\u7684\u75c5\u7406\u6539\u53d8\u3002<\/p>","protected":false},"author":1,"featured_media":4735,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[25],"tags":[103],"_links":{"self":[{"href":"http:\/\/www.tarzan-tech.com\/en\/wp-json\/wp\/v2\/posts\/710"}],"collection":[{"href":"http:\/\/www.tarzan-tech.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.tarzan-tech.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.tarzan-tech.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.tarzan-tech.com\/en\/wp-json\/wp\/v2\/comments?post=710"}],"version-history":[{"count":1,"href":"http:\/\/www.tarzan-tech.com\/en\/wp-json\/wp\/v2\/posts\/710\/revisions"}],"predecessor-version":[{"id":1707,"href":"http:\/\/www.tarzan-tech.com\/en\/wp-json\/wp\/v2\/posts\/710\/revisions\/1707"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/www.tarzan-tech.com\/en\/wp-json\/wp\/v2\/media\/4735"}],"wp:attachment":[{"href":"http:\/\/www.tarzan-tech.com\/en\/wp-json\/wp\/v2\/media?parent=710"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.tarzan-tech.com\/en\/wp-json\/wp\/v2\/categories?post=710"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.tarzan-tech.com\/en\/wp-json\/wp\/v2\/tags?post=710"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}