{"id":713,"date":"2022-03-10T15:27:04","date_gmt":"2022-03-10T07:27:04","guid":{"rendered":"http:\/\/www.tarzan-tech.com\/?p=713"},"modified":"2023-04-04T14:03:28","modified_gmt":"2023-04-04T06:03:28","slug":"recaros-commitment-to-expand","status":"publish","type":"post","link":"http:\/\/www.tarzan-tech.com\/en\/recaros-commitment-to-expand\/","title":{"rendered":"\u300aFrontiers\u300b\uff1a\u5854\u671b\u79d1\u6280WBP\u7cfb\u7edfTMDCT\uff08\u4e2d\u836f\uff09\u6cbb\u7597\u54ee\u5598\u7814\u7a76"},"content":{"rendered":"

\"\u300aFrontiers\u300b\uff1a\u5854\u671b\u79d1\u6280WBP\u7cfb\u7edfTMDCT\uff08\u4e2d\u836f\uff09\u6cbb\u7597\u54ee\u5598\u7814\u7a76\u63d2\u56fe\"<\/p>\n

\u8fd1\u65e5\u5317\u4eac\u4e2d\u533b\u836f\u5927\u5b66\u79d1\u7814\u56e2\u961f\u91c7\u7528WBP\u5168\u8eab\u4f53\u79ef\u63cf\u8bb0\u7cfb\u7edf\u7814\u7a76\u4e86TMDCT\u5728\u8c03\u8282Treg\/Th17\u7ec6\u80de\u514d\u75ab\u5e73\u8861\u4e2d\u7684\u4f5c\u7528\u548c\u5176\u76f8\u5173\u7684\u6f5c\u5728\u4ee3\u8c22\u548c\u80a0\u9053\u751f\u7269\u6807\u5fd7\u7269\u3002\u76f8\u5173\u6210\u679c\u53d1\u5e03\u5728\u82f1\u6587\u5b66\u672f\u671f\u520a\u300aFrontiers\u300b\u4e0a\u3002<\/p>\n

Yumei Zhou, Haihong Zhao, Tieshan Wang, Xiaoshan Zhao, Ji Wang and Qi Wang\uff0cAnti-Inflammatory and Anti-asthmatic Effects of TMDCT Decoction in Eosinophilic Asthma Through Treg\/ Th17 Balance. Frontiers, 2022.819728:<\/p>\n

\"\u300aFrontiers\u300b\uff1a\u5854\u671b\u79d1\u6280WBP\u7cfb\u7edfTMDCT\uff08\u4e2d\u836f\uff09\u6cbb\u7597\u54ee\u5598\u7814\u7a76\u63d2\u56fe1\"<\/p>\n

\n

\"\u300aFrontiers\u300b\uff1a\u5854\u671b\u79d1\u6280WBP\u7cfb\u7edfTMDCT\uff08\u4e2d\u836f\uff09\u6cbb\u7597\u54ee\u5598\u7814\u7a76\u63d2\u56fe2\"<\/p>\n

\u54ee\u5598\u2014\u2014\u662f\u4e00\u79cd\u96be\u4ee5\u63a7\u5236\u7684\u6162\u6027\u708e\u75c7\u6027\u75be\u75c5,\u5f71\u54cd\u7740\u5168\u74033\u4ebf\u591a\u4eba\u3002\u968f\u7740\u76ee\u524d\u7684\u4e0a\u5347\u8d8b\u52bf\uff0c\u9884\u8ba1\u52302025\u5e74\u8fd9\u4e00\u6570\u5b57\u5c06\u8fbe\u52304\u4ebf\u4eba.\u6839\u636e\u6743\u5a01\u62a5\u544a\u62a5\u5230,\u6bcf\u5e74\u6709250,000\u4f8b\u4e0e\u54ee\u5598\u76f8\u5173\u7684\u6b7b\u4ea1\u75c5\u4f8b,\u5176\u4e2d\u8bb8\u591a\u662f\u53ef\u4ee5\u907f\u514d\u7684(Christiansen Zuraw,2019\u5e74)\u3002<\/p>\n

\"\u300aFrontiers\u300b\uff1a\u5854\u671b\u79d1\u6280WBP\u7cfb\u7edfTMDCT\uff08\u4e2d\u836f\uff09\u6cbb\u7597\u54ee\u5598\u7814\u7a76\u63d2\u56fe3\"<\/p>\n

TMDCT <\/strong>\u662f\u4e00\u79cd\u4e2d\u836f\u914d\u65b9,\u7531\u5341\u4e8c\u79cd\u8349\u836f\u7ec4\u6210,\u53ef\u4ee5\u7f13\u89e3\u75c7\u72b6\u548c\u6cbb\u7597\u8fc7\u654f\u6027\u54ee\u5598\u3002\u7136\u800c,\u6f5c\u5728\u7684\u4f5c\u7528\u673a\u5236\u4ecd\u4e0d\u6e05\u695a\u3002TMDCT\u542b\u670912\u79cd\u4e2d\u836f,\u53ef\u6291\u5236\u8fc7\u654f\u6027\u54ee\u5598\u708e\u75c7,\u6291\u5236\u80a5\u5927\u7ec6\u80de\u8131\u9897\u7c92(Qin et al, 2021)\u3002\u5728\u6211\u4eec\u7684\u7814\u7a76\u4e2d\uff0c\u6211\u4eec\u7814\u7a76TMDCT\u5728\u8c03\u8282Treg\/Th17\u7ec6\u80de\u5e73\u8861\u8fc7\u7a0b\u4e2d\u8d77\u5230\u4e86\u79ef\u6781\u7684\u4f5c\u7528,\u5e76\u5728\u4f7f\u7528\u975e\u9776\u5411\u4ee3\u8c22\u7ec4\u548c16S rDNA\u6280\u672f\u63a5\u53d7TMDCT\u6cbb\u7597\u7684\u55dc\u9178\u6027\u54ee\u5598\u5c0f\u9f20\u4e2d\u63a2\u7d22\u4e86\u4e0eTreg\u548cTh17\u7ec6\u80de\u76f8\u5173\u7684\u6f5c\u5728\u4ee3\u8c22\u548c\u80a0\u9053\u751f\u7269\u6807\u5fd7\u7269\u3002<\/p>\n

\n

\"\u300aFrontiers\u300b\uff1a\u5854\u671b\u79d1\u6280WBP\u7cfb\u7edfTMDCT\uff08\u4e2d\u836f\uff09\u6cbb\u7597\u54ee\u5598\u7814\u7a76\u63d2\u56fe4\"<\/p>\n

OVA <\/strong>\u8bf1\u5bfc\u7684\u8fc7\u654f\u6027\u54ee\u5598\u5c0f\u9f20\u6a21\u578b\u548c\u5206\u7ec4OVA\u8bf1\u5bfc\u7684\u55dc\u9178\u6027\u54ee\u5598BALB\/C\u5c0f\u9f20\u6a21\u578b\u6309\u7167\u5148\u524d\u63cf\u8ff0\u7684\u65b9\u6cd5\u6784\u5efa(Dumas et al., 2018)\u3002\u7b80\u800c\u8a00\u4e4b,\u5728\u7b2c1\u5929\u548c\u7b2c14\u5929,\u5c062 mg OVA (Sigma-Aldrich,Cat#A5503)\u4e0e 2mg ImjectTM Alum Adjuvant (Invitrogen ,Cat#77161)\u548cPBS\u6df7\u5408\u540e\u8179\u819c\u5185\u6ce8\u5c04\u5c0f\u9f20\u3002\u4ece\u7b2c21\u5929\u5230\u7b2c25\u5929\u6ce8\u5c04\u540e,\u5728\u6311\u6218\u9636\u6bb5\uff0c \u5c0f\u9f20\u75281% OVA\u8fde\u7eed\u96fe\u531630\u5206\u949f,\u5982\u56fe1A\u6240\u793a\u3002<\/p>\n

\n

\"\u300aFrontiers\u300b\uff1a\u5854\u671b\u79d1\u6280WBP\u7cfb\u7edfTMDCT\uff08\u4e2d\u836f\uff09\u6cbb\u7597\u54ee\u5598\u7814\u7a76\u63d2\u56fe5\"<\/p>\n

\n

\"\u300aFrontiers\u300b\uff1a\u5854\u671b\u79d1\u6280WBP\u7cfb\u7edfTMDCT\uff08\u4e2d\u836f\uff09\u6cbb\u7597\u54ee\u5598\u7814\u7a76\u63d2\u56fe6\"<\/p>\n

Treg <\/strong>\u7ec6\u80de\u53ca\u5176\u6291\u5236\u6027\u7ec6\u80de\u56e0\u5b50(TGF-B\u3001IL-10)\u7684\u4ea7\u751f\u548c\u7ef4\u6301\u5bf9\u4e8e\u5728\u8fc7\u654f\u6027\u75be\u75c5\u4e2d\u8bf1\u5bfc\u8fc7\u654f\u539f\u8010\u53d7\u8d77\u5230\u81f3\u5173\u91cd\u8981\u7684\u4f5c\u7528(Palomares \u7b49,2017)\u3002\u6b64\u5916\uff0cFOXP3+ Treg\u7ec6\u80de\u901a\u8fc7\u6291\u5236\u5bf9\u8fc7\u654f\u539f\u7684\u53cd\u5e94,\u5728\u7ef4\u6301\u5916\u5468\u8010\u53d7\u6027\u65b9\u9762\u53d1\u6325\u5173\u952e\u6027\u4f5c\u7528(Noval Rivas\u548cChatila ,2016)\u3002\u8fd8\u5efa\u8bae\u8fc7\u654f\u539f\u7279\u5f02\u6027\u514d\u75ab\u6cbb\u7597\u65b9\u6848\u589e\u52a0Treg\u7ec6\u80de\u7684\u6570\u91cf(Radulovic \u7b49,2008)\u3002\u6b64\u5916,\u4e00\u4e9b\u7814\u7a76\u53d1\u73b0Treg\u7ec6\u80de\u5728\u9884\u9632\u8fc7\u654f\u6027\u54ee\u5598\u6c14\u9053\u708e\u75c7\u65b9\u9762\u5177\u6709\u4e0d\u53ef\u66ff\u4ee3\u7684\u4f5c\u7528(Tortola et al., 2019; Sun et al, 2020)\u3002\u540c\u65f6\u589e\u52a0Treg\u6216Breg\u7ec6\u80de\u7b49\u514d\u75ab\u6291\u5236\u7ec6\u80de\u7684\u514d\u75ab\u6291\u5236\u529f\u80fd\u53ef\u80fd\u5bf9\u5f7b\u5e95\u6cbb\u6108\u8fc7\u654f\u6027\u54ee\u5598\u81f3\u5173\u91cd\u8981\u3002<\/p>\n

\"\u300aFrontiers\u300b\uff1a\u5854\u671b\u79d1\u6280WBP\u7cfb\u7edfTMDCT\uff08\u4e2d\u836f\uff09\u6cbb\u7597\u54ee\u5598\u7814\u7a76\u63d2\u56fe7\"<\/p>\n

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\"\u300aFrontiers\u300b\uff1a\u5854\u671b\u79d1\u6280WBP\u7cfb\u7edfTMDCT\uff08\u4e2d\u836f\uff09\u6cbb\u7597\u54ee\u5598\u7814\u7a76\u63d2\u56fe8\"<\/p>\n

\u5854\u671b\u79d1\u6280<\/strong>\u7814\u53d1\u751f\u4ea7\u76844\u901a\u9053\u5c0f\u9f20\u5168\u8eab\u4f53\u79ef\u63cf\u8bb0\u7cfb\u7edf\uff08WBP-4R\uff09\u53ef\u5bf9\u6e05\u9192\u81ea\u7531\u6d3b\u52a8\u52a8\u7269\u547c\u5438\u53c2\u6570\u8fdb\u884c\u6d4b\u91cf\uff0c\u5982\u547c\u5438\u9891\u7387\uff0c\u6f6e\u6c14\u91cf\uff0c\u6c14\u9053\u9ad8\u53cd\u5e94\u6027\u6d4b\u8bd5\uff08Airway hyperresponsiveness\uff0cAHR\uff09\u7b49\u3002<\/p>\n

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\"\u300aFrontiers\u300b\uff1a\u5854\u671b\u79d1\u6280WBP\u7cfb\u7edfTMDCT\uff08\u4e2d\u836f\uff09\u6cbb\u7597\u54ee\u5598\u7814\u7a76\u63d2\u56fe9\"<\/p>\n

Sun, L., Fan, M., Huang, D., Li, B., Xu, R., Gao, F., et al. (2021). Clodronate-loaded Liposomal and Fibroblast-Derived Exosomal Hybrid System for Enhanced Drug Delivery to Pulmonary Fibrosis. Biomaterials 271, 120761. doi:10.1016\/j.biomaterials.2021.120761<\/p>","protected":false},"excerpt":{"rendered":"

\u91c7\u7528WBP\u5168\u8eab\u4f53\u79ef\u63cf\u8bb0\u7cfb\u7edf\u7814\u7a76\u4e86TMDCT\u5728\u8c03\u8282Treg\/Th17\u7ec6\u80de\u514d\u75ab\u5e73\u8861\u4e2d\u7684\u4f5c\u7528\u3002<\/p>","protected":false},"author":1,"featured_media":4742,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[24,25],"tags":[93,94],"_links":{"self":[{"href":"http:\/\/www.tarzan-tech.com\/en\/wp-json\/wp\/v2\/posts\/713"}],"collection":[{"href":"http:\/\/www.tarzan-tech.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.tarzan-tech.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.tarzan-tech.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.tarzan-tech.com\/en\/wp-json\/wp\/v2\/comments?post=713"}],"version-history":[{"count":1,"href":"http:\/\/www.tarzan-tech.com\/en\/wp-json\/wp\/v2\/posts\/713\/revisions"}],"predecessor-version":[{"id":1677,"href":"http:\/\/www.tarzan-tech.com\/en\/wp-json\/wp\/v2\/posts\/713\/revisions\/1677"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/www.tarzan-tech.com\/en\/wp-json\/wp\/v2\/media\/4742"}],"wp:attachment":[{"href":"http:\/\/www.tarzan-tech.com\/en\/wp-json\/wp\/v2\/media?parent=713"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.tarzan-tech.com\/en\/wp-json\/wp\/v2\/categories?post=713"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.tarzan-tech.com\/en\/wp-json\/wp\/v2\/tags?post=713"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}